With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. According to Penn State University, if you are allergic to birch pollen, you are likely to also be allergic to celery seeds. 2002;27(3):153-156. 2018;127:237-244. 2008;63(2):243-4. One tablespoon (6.5 grams) of celery seeds provides (2): Celery seeds are low in calories, with a tablespoon providing about 25 calories. The essential oil produces sedative effects. Extract Consider therapy modification.Mousa 2010, Spolarilch 2007, Stanger 2012, Ulbricht 2008, Thrombolytic agents: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of thrombolytic agents. An updated phytopharmacological review on medicinal plant of Arab region: Apium graveolens Linn. For example, one test-tube study found that celery seed extract fought off H. pylori bacteria, which are found in the digestive tract of certain individuals and may lead to stomach ulcers (25, 26). Wild celery can refer to Vallisneria spiralis L., an aquatic perennial. A study by the Journal of Pharmaceutical Biology in 2010 showed how the alkaloids, tannins and flavonoids in celery improve mucus production, which in turn controls gastric acid. J AOAC Int 2001;84(4):1135-1143. Christensen, L. P. and Brandt, K. Bioactive polyacetylenes in food plants of the Apiaceae family: occurrence, bioactivity and analysis. Research suggests that certain compounds in celery seed may have benefits in treating gout. Celery root extract might decrease how quickly the body breaks down venlafaxine. View abstract. People with low blood sugar, acute kidney inflammation, or an allergy to celery seeds or birch pollen should also avoid taking celery seed (34). Consider therapy modification.Mousa 2010, Spolarilch 2007, Stanger 2012, Ulbricht 2008, Allergy, including dermatitis and anaphylaxis (rare), and phototoxicity to celery and its falcarinol content have been described.Christensen 2006, Duke 2002, Khan 2009, Pauli 1985, Raised liver enzymes have been noted in phase 3 trials of dl-3-n-butylphthalide 800 mg/day.Cui 2013, Celery seed has GRAS status when used as a food.Khan 2009 Neurotoxicity in rats due to the seed's chemical constituent falcarinol has been demonstrated.Christensen 2006 While celery root contains furocoumarins (particularly psoralens), the concentration in normal dietary intake is at least 1,000-fold lower than the no observed effect level for developing liver or cancer in rats.Dolan 2010 Limited toxicological studies suggest celery seed extract lacks toxicity at normal dosages.Powanda 2015. WebA human study demonstrating the effectiveness of a celery seed extract standardized to 85% 3nB recently appeared in the Natural Medicine Journal. Lithium: Celery seed may alter how this medication is excreted in the body. Celery seeds are a versatile spice and a concentrated source of nutrients. It has 3 to 5 segmented leaves and flowers with small white petals. Use them as a spice rub for grilled meat. Celery juice might decrease how quickly the liver breaks down and removes aminopyrine. View abstract. Contains 75 mg celery seed/63.75 mg 3nB extract per.Celery is often called a negative calorie food but it certainly isnt lacking in nutrition. In fact, one large review associated magnesium-rich diets with an up to 14% reduced risk of diabetes (21, 24). Consider therapy modification.Mousa 2010, Spolarilch 2007, Stanger 2012, Ulbricht 2008, Salicylates: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of salicylates. See additional information. Celery seeds contain methanolic and hexane extracts, which help with circulation. Celery seeds are also rich in a lesser-known mineral called manganese. WebOf these, 3-n-butylphthalide (3nB) is one of the most well researched. People with active kidney inflammation should not take celery seed. The seed is used as a spice. In the UK Women's Cohort Study conducted in 13,958 women (with approximately 4 years of follow-up), consumption of an additional portion of celery (among other plants) was inversely associated with sleep duration.Noorwali 2018, Limited studies in rodents suggest celery seed extract possesses hypoglycemic effects.Yusni 2018, Very limited clinical data exist regarding the effects of celery leaf or seed extract in diabetes. Some research shows that applying a gel containing 5% to 25% celery extract to the. Tuetun, B., Choochote, W., Pongpaibul, Y., Junkum, A., Kanjanapothi, D., Chaithong, U., Jitpakdi, A., Riyong, D., Wannasan, A., and Pitasawat, B. (2017). Iron deficiency is the most common micronutrient deficiency worldwide, but eating more iron-rich foods has been shown to lower your risk of deficiency and subsequent anemia (16, 17). Banerjee S, Sharma R, Kale RK, Rao AR. With many different standardizations, the dosages may differ between supplements. Food Chem.Toxicol. The results showed that beta-selinene demonstrated a wide variety of antioxidant and anti-inflammatory properties. To illustrate, celery extract protects the lining of the stomach, esophagus and duodenum and can prevent peptic ulcers. Last medically reviewed on July 23, 2019. View abstract. Bleeding may occur. Celery Seed Extract Side Effects | livestrong Medically reviewed by Drugs.com. Clin Exp Allergy 1996;26:1161-70. Research feed. But there are some gout remedies you can try at home to prevent or treat future, While gout usually first affects joints in your feet, such as your big toe, its also possible to develop gout in your other joints, including your. A few drops of celery seed oil combined with body lotion creates a natural repellent that keeps mosquitoes at bay (x). See additional information. Celery seeds contain NBP, an oily compound with a diuretic effect that helps with the detoxification process. These results indicate that celery seed may help reduce gout-related inflammation. The safety of taking celery oil and seeds if you are breastfeeding is unknown, so it's best to avoid their use if that's the case. Prospective, multicenter evaluation of a polyherbal supplement alongside standard-of-care treatment for mild knee osteoarthritis. View abstract. Bleeding may occur. Jeanmougin, M., Varroud-Vial, C., and Dubertret, L. [Phototoxic side-effect following celery ingestion during puvatherapy]. Despite their small size, celery seeds have an Li S, Li L, Yan H, et al. We include products we think are useful for our readers. 1990;126(10):1334-1336. Through dietary interventions, you may be able to reduce the levels of uric acid in the blood and minimize painful flare-ups. A lower bone mineral density is associated with an increased risk of fractures, especially in older adults. Strain the seeds from the water and enjoy. If you notice negative side effects when taking herbal supplements, see your doctor. Inhibition of cell adhesion, antiangiogenic properties, proapoptosis, and other effects have been demonstrated in studies using human cancer cell lines.Iyer 2019, Kasiri 2018, Kowalczyk 2017, Sung 2016 In vitro and rodent studies suggest essential oil from celery may also possess cytotoxic and antimutagenic properties.Christensen 2006, Hashim 1994, Lim 2013, Zheng 1993, Celery extract has demonstrated vasorelaxant effects on isolated rat aortic rings.Jorge 2013 Celery seed extract exerted hypotensive effects in hypertensive, but not normotensive, rats, possibly due to the n-butylphthalide content.Moghadam 2013, Tang 2017 Limited studies in rodents report improved lipid profiles with celery seed extracts.Abd El-Mageed 2011, Iyer 2011, Iyer 2019, Rouhi-Boroujeni 2015 Additional effects in cardiovascular disease include decreased secretion of proinflammatory cytokines.Tang 2017, Limited clinical studies have been conducted to evaluate the effects of the extracted compound butylphthalide in strokeWang 2018; one study demonstrated superiority of 90-day treatment with dl-3-n-butylphthalide (a synthetic variation of l-3-n-butylphthalide, an extract from seeds of A. graveolens) over aspirin in patients with acute ischemic stroke.Cui 2013 The synthetic version of the compound is clinically approved as an anti-ischemic agent in China.Abdoulaye 2016, In older studies, 3-n-butylphthalide showed sedative and anticonvulsant effects in rodents.Khan 2009 In induced Parkinson disease models in mice, extracts from whole A. graveolens plant improved behavioral performance, oxidative stress parameters, and monoamine oxidase A and B activity.Chonpathompikunlert 2018, Huang 2010 Other studies in rodents report improvements in cognition and depression, and modulation of endogenous antioxidant and neurotransmitter systems.Boonruamkae 2017 Reviews exist regarding neuroprotective effects of the flavone luteolin, which is found in several plant products, including celery.Nabavi 2015, Clinical studies are lacking. Effect of celery extract on thyroid function; is herbal therapy safe in obesity? 1985;3:85. However, certain individuals should avoid supplemental celery seed due to safety concerns, particularly pregnant women. Parmesan or Parmigiano-Reggiano is a hard Italian cheese. Gral N, Beani JC, Bonnot D, et al. If you have low blood pressure, you should use caution when considering celery seed extract as a supplement. Pregnant women should not use celery seed because it may lead to uterine bleeding and muscle contractions in the uterus, which could cause miscarriage. Evidence from a preliminary study in Natural Medicine Journal in April 2013 indicated that celery seed extract may decrease both systolic and diastolic blood pressure. Again, no side effects were noted other than the diuretic effect with no changes in the sodium and potassium balance. The celery seed extract appeared to be particularly helpful for sufferers of gout, as 3nB appears to lower the production of the uric acid that causes gout by inhibiting the enzyme xanthine oxidase. Despite their small size, celery seeds have an impressive nutrient profile. View abstract. Healthline Media does not provide medical advice, diagnosis, or treatment. 9 For the study, 30 middle Celery seeds can also protect against Irritable Bowel Syndrome, urinary tract infection and gout (x). About one-half of adults in the United States say they have used one or more supplements in the past 30 days. 2005;221(1):11-20. Taking celery juice with acetaminophen prolongs the effects of acetaminophen. Vasodilatory action mechanisms of apigenin isolated from Apium graveolens in rat thoracic aorta. For example, theyre a great source of essential minerals like calcium, manganese, and iron. Celery seed is contraindicated in pregnancy. Other organic components include isovalerianic aldehyde, propionic aldehyde, and acetaldehyde.Christensen 2006, Garg 1980, Khan 2009, Madjarova 1979, Marongiu 2013, Nagella 2012, In in vitro studies, luteolin extracted from celery suppressed proinflammatory cytokines and upregulated cyclooxygenase expression.Christensen 2006, Kasiri 2018, Kim 2014, Park 2013 Further studies have suggested glycosides from the ethanol whole plant extract possess anti-inflammatory effects and inhibit nitric oxide production.Zhu 2017, Antifungal, antibacterial, and antiprotozoal activity has been described for celery oil.Baananou 2013, Marongiu 2013, Nagella 2012, Nguyen 2014 Activity against uropathogenic Escherichia coli bladder and kidney infections in rodents has been demonstrated.Sarshar 2018, Antioxidant activity has been demonstrated and may account for several observed effects of celery.Kooti 2017 Fresh celery flavonoid extracts reduced oxidative stress in rats and mice, as measured in the liver, mitochondria, and spermatozoa.Cao 2012, Choi 2011, Kolarovic 2010, Kooti 2014, Li 2014, Studies have focused on the role of apigenin, extracted from celery seed, as a potential chemotherapeutic agent. Theyre sold as whole seeds, crushed, or as a ground spice. 1986;4(3):195-199. Some of the phenolic compounds in celery seeds can cause your skin to become very sensitive to the sun's UV rays, according to Penn State Hershey. A celery seedflavored soda, Dr. Brown's Cel-Ray, is available. Bauer L, Ebner C, Hirschwehr R, et al. Fraser L and et al. Allerg.Immunol. WebDose: to 5/8 tsp whole celery seeds, chewed/ground, with breakfast Effect on Cum Volume: Solid increase (~11%) Effect on Sperm Volume: Significant increase (~26%) Effect on Libido: Solid increase, on average, but this effect proved uneven; erections come easier and Used in cooking, celery seed spice is considered likely safe in normal quantities. Adult. 1993;19:77-86. DOI: Pauff JM, et al. Its most commonly used to season soups, vegetable dishes, or homemade salad dressings. You should avoid taking celery seed extracts and supplements if you are pregnant or trying to conceive. Boffa, M. J., Gilmour, E., and Ead, R. D. Celery soup causing severe phototoxicity during PUVA therapy. Moneret-Vautrin, D. A. and Kanny, G. [Food-induced anaphylaxis. Sultana S, Ahmed S, Jahangir T, Sharma S. Inhibitory effect of celery seeds extract on chemically induced hepatocarcinogenesis: modulation of cell proliferation, metabolism and altered hepatic foci development. Magnesium plays an important role in blood sugar control and helps increase your cells response to insulin, a hormone that regulates blood sugar levels (21, 22, 23). Though research is limited, a few animal and test-tube studies have found celery seed extract to possess antioxidant properties (1, 29). Theyre most commonly added to soups and other savory recipes, but can also be used to make tea. View abstract. Celery seed is also used for: There are no human scientific studies that show whether celery seed helps treat these conditions or any others. One study on Varbenaceae, a medicinal herb, examined the antioxidant properties of beta-selinene. Some of the chemicals in celery stems and seeds can cause the skin to become very sensitive to the sun's UV rays. Taking celery might decrease how well the body gets rid of lithium. Levothyroxine is used for low thyroid function. 2010;48(1):93-98. Use sunscreen or sunblock lotions. Zhou Y, Taylor B, Smith TJ, Liu ZP, Clench M, Davies NW, Rainsford KD. Late in the 19th century, various celery tonics and elixirs appeared commercially, generally containing the juice of crushed celery seeds and often with a large amount of alcohol. Based on the positive results in this small pilot study, a larger 70-patient study was conducted. Online ahead of print. Al-Howiriny T, Alsheikh A, Alqasoumi S, Al-Yahya M, ElTahir K, Rafatullah S. Gastric antiulcer, antisecretory and cytoprotective properties of celery (Apium graveolens) in rats. J Ethnopharmacol. This article explores Parmesan cheese's nutritional benefits, uses, and potential. Celery (Apium graveolens) is a plant that grows throughout the world. Ann.Dermatol Venereol 2005;132(6-7 Pt 1):566-567. Celery seed has been used as a food preservation in India for thousands of years. The symptoms, likely due to a CYP2D6-dependent interaction, resolved upon cessation of the celery root extract.Khalid 2016, In a study in rats given an extract of fresh celery, increased plasma captopril levels were reported.Siska 2018, Antithrombotic effects have been described for celery seed extracts.Cui 2013 Potentiation of monoamine oxidase inhibitors is possible.Jger 2013, Agents with antiplatelet properties: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of agents with antiplatelet properties. DOI: Dolati K, et al. Among other things, the minerals in celery seeds support bone health and blood sugar regulation. Celery seeds are rich in many essential nutrients for bone health like calcium, manganese, magnesium, and phosphorus. Anaphylaxis after Oseltamivir (Tamiflu) therapy in a patient with sensitization to star anise and celery-carrot-mugwort-spice syndrome. Gout is triggered when uric acid builds up within the joints. DeLeo, V. A. Photocontact dermatitis. Subjects received 75 mg of the celery seed extract twice daily for three weeks. Most people can safely use celery seeds in cooking. Therapeutic Research Faculty 2020. Needless to say, regular consumption of foods high in polyphenols has been documented to combat radical damage during oxidative stress and help promote cellular longevity. (Paris) 1995;27(3):91-93. Celery Seeds: Benefits, Uses, And More Celery (Apium graveolens) contains many beneficial plant compounds, which are found primarily in the seeds of the plant. Stalking hypertension. Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Reducing uric acid levels with luteolin might reduce the frequency of gout flare-ups. (2017). This could make the effects of blood thinners stronger and raise the risk of bleeding. So it could make the effects of other diuretics stronger and raise the risk of dehydration. This could change the effects and side effects of these medications. Singh A, Handa SS. Celery seeds have a spicy odor and a spicy, slightly bitter taste. Though small in size, celery seeds are of great nutritional value and provide many health benefits. Eating iron-rich food helps your body produce red blood cells and may prevent anemia. In fact, they serve the same purpose as cranberries in treating bladder disorders, cysts and kidney problems (x). Learn more. Avicenna J Phytomed 2021;11(1):44-53. Celery seeds consist of the oil (petroselinic, linoleic, palmitic, and oleic fatty acids) and volatile compounds, mostly monoterpene hydrocarbons.Kooti 2017 The major WebCelery seed, whether taken as the extract or even as powdered celery seed that you can get at any grocery store, is very useful stuff. Dietary fiber and the short‐chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice. Combined with the high fiber content, celery seed extract can help maintain regularity and reduce bloating (x). Other medications: Celery seed may interact with lithium, thyroid medications, and sedatives. Without enough dietary iron, your body cannot produce enough red blood cells. This study suggests that luteolin might provide some protection from uric acid-induced inflammation in gout. All rights reserved. Healthline only shows you brands and products that we stand behind. WebMy recommendation is to either consume eight ribs of celery per day or take a celery seed extract standardized to contain 85 percent 3nB and other celery phthalides at a dosage A new French multicenter study]. Consider therapy modification.Choi 2017, Fan 2017, Heck 2000, Izzat 1998, Jiang 2005, Kruth 2004, Lambert 2001, Mousa 2010, Shi 2012, Spolarilch 2007, Stanger 2012, Tsai 2013, Ulbricht 2008, Vaes 2000, Wang 2015, Herbs (anticoagulant/antiplatelet properties): Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of other herbs (anticoagulant/antiplatelet properties). Nitric oxide is an important compound in the body, but it can produce oxidative stress and inflammation in large amounts. CELERY Reviews and User Ratings: Effectiveness, Ease of Use, and Rouhi-Boroujeni H, Hosseini M, Gharipour M, Rouhi-Boroujeni H. Is herbal therapy safe in obesity? Lastly, celery seeds also contain magnesium and phosphorus. Celery seed has "generally recognized as safe" (GRAS) status when used as a food, according to the US Food and Drug Administration (FDA). Some studies have suggested it may modestly improve blood pressure, cholesterol, and C-reactive protein Scientific Name(s): Apium graveolens L. var dulce (Mill.) hour/mL in rats, which were very low blood apigenin levels [ 58 ]. Adverse Effects of Celery Silverstein, S. R., Frommer, D. A., Dobozin, B., and Rosen, P. Celery-dependent exercise-induced anaphylaxis. As medicine, celery seed powder or extract have most often been used by adults in doses of 1000-1500 mg by J Food Biochem 2020:e13399. Theyre low in calories and provide relatively equal amounts of carbs, protein, and fat. (2010). These benefits may also be found in the beta-selinene in celery seed, but this study didnt test celery specifically. View abstract. Br J Dermatol. Antioxidant, anti-inflammatory, antimicrobial, GI, and cytotoxic effects of celery have been described. Celery seeds contain non-heme iron. A review of the antioxidant activity of celery (. Anti-gouty arthritis and anti-hyperuricemia properties of celery seed extracts in rodent models. This information should not be used to decide whether or not to take this product. Celery: Health Benefits, Nutrients, Preparation, and More Celery Seed Extract Blood thinners include aspirin, warfarin (Coumadin), and clopidogrel (Plavix). An allergy to celery seed may cause rare but severe life-threatening reactions in some people. Healthline Media does not provide medical advice, diagnosis, or treatment. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. View abstract. Palgan K, Gtz-Zbikowska M, Tykwinska M, Napirkowska K, Bartuzi Z. Celery-cause of severe anaphylactic shock. Bonnin, J. P., Grezard, P., Colin, L., and Perrot, H. [A very significant case of allergy to celery]. Celery oil and celery seeds are LIKELY SAFE when taken by mouth in food amounts. Furthermore, consuming celery seed extract with a balanced diet plan could help to manage overall cholesterol levels. A handful of celery seeds will help cleanse your urinary tract and keep it void of any unwanted bacteria. These red blood cells deliver oxygen from your lungs to other parts of your body (14). Im not sure what the problem is. Polyphenols are beneficial compounds in certain plant foods. View abstract. All rights reserved. 2010;65(6):792-3. 3-31-1984;13(14):871-874. During June and July, small white flowers bloom and later bear the smooth gray seeds. CELERY: Overview, Uses, Side Effects, Precautions, But if youre experiencing painful symptoms of gout and are interested in exploring alternative treatment options, speak with your doctor for more information. Can drinking this bright green juice really give your body a healthy boost? The dosage Consider therapy modification.Mousa 2010, Spolarilch 2007, Stanger 2012, Ulbricht 2008, Anticoagulants: Herbs (anticoagulant/antiplatelet properties) may enhance the adverse/toxic effect of anticoagulants. One tablespoon (6.5 grams) of the seeds provides 12% of the RDI for this mineral. Celery seeds contain several substances, including: Scientists have not studied celery seeds in children, so it is not recommended for use in children under 18. Here's. This may lead to a lower bone mineral density, which is a measure of the number of minerals present in a certain volume of bone (3, 4, 5). Teng CM, Lee LG, Ko SN, et al. Since then, the plant has been widely used as a food and for medicinal purposes. Our website services, content, and products are for informational purposes only. View abstract. The celery plant is slender and stands about 2 to 3 feet tall. J Vector Ecol. Hepatoprotective activity of two plants belonging to the Apiaceae and the Euphorbiaceae family. IgE cross-reactivity between birch pollen, mugwort pollen, and celery is due to three distinct cross-reacting allergens: immunoblot investigation of the birch-mugwort-celery syndrome. However, celery was just one part of their diet. IMPORTANT: Celery seed and celery extract should be avoided by pregnant women. There has been no significant increase for me. Ballmer-Weber, B. K., Hoffmann, A., Wuthrich, B., Luttkopf, D., Pompei, C., Wangorsch, A., Kastner, M., and Vieths, S. Influence of food processing on the allergenicity of celery: DBPCFC with celery spice and cooked celery in patients with celery allergy. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. View abstract. View abstract. Essential oil of mountain celery seeds is produced from a related species, Cryptotaenia japonica, and should not be confused with A. graveolens.Duke 2002, Khan 2009, USDA 2019, Celery originated as a wild plant that grew in salt marshes around the Mediterranean Sea.