We are at a loss as both embryos transferred (one late last year and one last month) were PGS normal. I would Love and Need your opinions on this. I also stopped working night shifts (Im a nurse) to reduce my stress levels but that didnt help either. I had a PGT normal day 7 embryo that unfortunately resulted in a chemical. 2 - IUIs both chemical My RE also encouraged us to just try another transfer rather than an ERA after our first chemical but then was on board after the second chemical happened. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. How fast embryos grow has an impact on success rates for untested embryos. My RE didnt change a thing between round 1 and round 2, and I didnt do anything differently. Another thing to consider: Has your doctor done a hysteroscopy? Find advice, support and good company (and some stuff just for fun). But it seems like the majority of twin pregnancies result in healthy babies. Hi! As for boosting chances with two put back it should not be the trick. Im trying not to fixate on my last embryo being a day 7. Other studies seem to suggest a 8-11% chance of miscarriage with a euploid transfer. This ended up working for me after my biochemical pregnancy. Preimplantation genetic testing (PGT) is the process of testing embryos created during in vitro fertilization (IVF) to determine the presence of genetic abnormalities that can lead to pregnancy complications, birth defects, congenital disease and/or miscarriage. A recent meta-analysis by Simopoulou et al. I think it would be worth it to do a endometrial receptivity analysis to test your implantation window. Has anyone experienced a failure or chemical pregnancy when transferring a PGS normal embryo *AND* being on an autoimmune protocol? I've already previously had 2 hysteroscapies (previously had a uterine septum - one hysteroscapy removed it, the other confirmed there was no scar tissue left). And since then Ive had medical issues that havent allowed me to try again until last month. Not exactly! Thanks for sharing! Check here for the full glossary (please excuse the repeated terms!). Have you ever had an endometrial biopsy to look for infection? Took THREE rounds of antibiotics for mine to clear. We had PGS/PGD testing and an ERA. When questioned as to why nothing was working, his response was sometimes it just doesnt happen and we dont know why. It sucks cause I only have one shot left at this and Im already against odds cause its a day 7 embryo , So RE doesnt think i need ERA because I did get pregnant. You guys have given me so much support and reassurance that I'm not alone in this ordeal. Capalbo et al. Early Pregnancy Loss - Miscarriage Doctor in Los Angeles - USC Fertility I pay completely out of pocket for everything so the added expense was not something I wasnt looking forward to, but Im happy I went through with it. How does anyone not go completely crazy through this whole process???? Dr is responsible for allowing . Embryoman (Sean Lauber) is a former embryologist and creator of Remembryo.com. This was my only PGS normal embryo so I have to re-do that as well.. Dear RLM11, so sorry for your losses, I know how devastating it is! After my negative, we did ERA and had a hysteroscopy to correct a small septum. I will say that I have heard a LOT of stories of people having failures with PGS embryos followed by successes- on here and on instagram. PGS Normal FET Results in Chemical Pregnancy *with* autoimmune protocol, Need some Love!!! PGS (PGT-A) success rates - PGS Testing (PGT-A) - Remembryo I paid a fortune for those sessions (I dont have insurance). PGT-A is able to evaluate the % of cells that are abnormal in a biopsy sample and if theres a mix of euploid and aneuploid cells then the embryo is a mosaic. How did your pregnancy turn out? Feeling more confused than ever. Have they tried changing your protocol (ie from natural to artificial cycle)? Chemical Pregnancy: Causes, Symptoms & Treatment - Cleveland Clinic Im still u sure if this will go to term, but getting a 2nd opinion from a specialist in RPL sure has made a difference. Would you ladies push next time for a different protocol? I did do another round of IVF and am now 17 weeks pregnant. PGT-A (formerly PGS testing) is a technique that determines the number of chromosomes in the cells of an embryo. Success rates for graded euploids are given here https://www.remembryo.com/pgs-success-rates/#Embryo_grades_and_PGS_success_rates. So what if the embryos are euploid? Besides that, there are no gaurantees of both sticking. If you want to read more about rebiopsying embryos, check out my archives for embryo rebiopsy. ERA testing: Hi lovely people , as per - Fertility Network UK Both Chemical pregnancies my lining was under 7. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. LBR was associated with morphologic parameters of euploid blastocysts, especially in women <30 years old. (2014)found no difference inongoing pregnancieswith Day 5 or 6 euploids (about 50%). It's my second transfer. She says that with PGS tested embryos my rate to achieve pregnancy is 70% and a twin pregnancy is at 50%. Definitely heartbroken but trying to look forward. I actually didnt have embryos to bring with me when we switched. I was more relaxed overall at the second transfer, and maybe that helped. 144 abnormal (aneuploid/mosaic) embryos and their outcomes. Hi, i didnt have chemicals, I had bfn for my first two transfers. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. I just wish we had more answers so we can prepare for the next . Maybe the wash too? How about a mosaic? Please whitelist our site to get all the best deals and offers from our partners. For more up-to-date information on this topic check out my other posts that are tagged withPGS (PGT-A) success rates. It provides a greater scope of information to geneticists, it reveals mosaicism within the embryos, as well as minimising the risk of receiving false positive or negative results. Unfortunately this isnt very clear at this point. But if you dont like the extra meds you could talk with your current or new clinic about not doing it and get their thoughts on it. Does PGT-A reduce the chances of miscarriage? Should I just ask for this to be done regardless? Or a fully aneuploid embryo? So weve been ttc for almost 2 years. For these groups, about 50% of biopsies had noeuploidembryos. After that we decided to just go straight to IVF given the chance of successful pregnancy with IUI was very low. Thought just because your embryo iseuploidthat grades dont matter anymore? I know how hard this all is. Pre-implantation Genetic Testing for Aneuploidies (also known as PGT-A, or historically known as PGS or CCS) is a diagnostic tool to tell your fertility doctor which embryos are likely to be chromosomally-normal and thus which to transfer. I had been on birth control since I was 18 and had no idea what to expect when I came off it. My doctor thought it was possibly due to retained products of conception. I just found out today that I've only got 2 larger follicles and 3 smaller ones that are growing but are quite behind the 2 larger ones. Existing data show that the live birth rate is between 60-80% when a single frozen embryo is transferred in a second cycle. After multiple necessary hysteroscopies, multiple retrievals, multiplefailed transfers, and 2 chemical pregnancies, I finally decided to get a 2nd opinion. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. I don't know how many more cycles I can do as my emotional reserve is running low. Reply Share React operationpepper Dec 22, 2015 3:42 PM Tiegs (2020) in their multicenter prospective study transferred 414 blastocysts that were only tested using PGT-A after the pregnancy outcome. That said, Im still glad that I pursued additional testing and second opinions just in case. 1st IVF Cycle with initial low beta results, Day 6 Blastocysts / PGS / embryo "Hunger Games". This may be used to avoid a gender-linked genetic disorder or (more rarely) for family balancing. They may be able to use the same sample as the ERA if you do both. What are the chances of having a miscarriage after transferring a PGT-A tested euploid embryo? It is seriously invaluable to me. Thinking of you , Thank you Yes, its A LOT and its weighing heavy on me since last week (when I got the call from my RE). Did your RE have you take anything other than progesterone and estrogen and aspirin? While my clinic has had great success with PGS transfers they did say they expect implantation rates to end up averaging 90% for PGS normal embryos and I believe miscarriage rates are also lower. He provides weekly summaries of the latest IVF research and posts on Facebook, Instagram and TikTok regularly. Last January we found out we were pregnant but had a miscarriage at 7 weeks. I have considered going to Braverman in NYC but I think that Kofinas tested me for everything Braverman tests for. I know that every cycle + embryo is different, but it's so hard to not compare cycles. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. Did anyone else have success after failure with PGS? Ive had two chemicals and my RE suggested doing an endometrial receptivity assay (ERA). It kind of makes me wonder what they get out of their alternative recommendations. Embryoman (Sean Lauber) is a former embryologist and creator of Remembryo.com. Is it because they were early blastocysts? TTC 3 years Terms are highlighted every 3rd time to avoid repetition. I know in our case our embryos had epigenetic issues which meant that our baby that we miscarried probably had structural issues. Its very disheartening though. You can check out my summary of the study here. Next Generation Sequencing (NGS) is a new technique which boasts an impressive 99.98% consistency rate for its results. I did PGS testing. Zhao et al. Liebermann et al. (2017)found no difference in survival rates of embryos that were thawed and biopsied, then refrozen. Its so heartbreaking but Im trying to find some hope so I can move forward. I can totally see not doing it though. I honestly wish I had but thats all hindsight now knowing what I knew. You cant compare the per retrieval and per transfer stats against each other directly. I have a similar story. Does it still matter? I was wondering what protocol were you on for your second transfer? They havent discontinued my medication they want me to continue until further instructions. Best of luck on your next FET! MENTS I am also going through a chemical pregnancy this week, but with an untested embryo (so, that's very likely the reason for my loss). Good luck! (2021) in their retrospective multicenter study compared the transfer of 1000 mosaic embryos and over 5500 euploid embryos between 2015 and 2020. They stratified the mosaics based on the specific type of abnormality, and whether they were <50% mosaic or >50% mosaic (meaning the mosaic embryos had a mix of either less or more than 50% aneuploid cells with euploid cells). For this group theyll have a better idea of what to expect. I had also changed from an estradiol tablet to estradiol patches in my first FET. They found that: If you want to read my summary of this paper, check here. After 10 days, they came back and said that it was low and that i should mentally prepare myself for a chemical pregnancy. Any experiences with Day 6 blastocyst - Fertility Network UK Bradley et al. Im sorry for your loss My first was also a frozen transfer and I agree, there is more prep involved. My AMH was low, around 1.5, FSH was slightly high, and follicle count was low normal. Your doctor sounds JUST like mine did before I switchedpushing surrogacy and unwilling to try anything differently. And I can't say thats the sole reason this one stuck, but it is the one thing we did differently, and here I am. Consult with your doctor before making any treatment changes. Has anyone had a similar experience but had a viable pregnancy. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. This was our first trial. (2019) STAR trial represents the best data that we have currently, and it shows no benefit with PGT-A reducing miscarriage in the general population. On September 20th, we did my first IVF cycle. We have one (and only one) 4bb PGS normal embryo. I also know that no one can make this decision for me. Your experience is so inspiring, thank you for sharing . We are currently looking to use a gestational surrogate in Texas. PGS enhances the success of IVF but not in all cases; the success rates vary by age. I also tested positive for anti-thyroid antibodies. Pgs testing results The Bump PGT-A is generally recommended for women >35, and the majority of cycles in the US in 2020 were for women >35 (62%). Viotti et al. Is it significantly less for a pregnancy with an embryo that tested pgt normal? I haven't done the transfer yet due to various reasons, and even though nothing is guaranteed, I like going into it knowing that I have a better chance because it is a normal embryo. All that to say, it's likely that there actually was something wrong with that embryo - but it's worthwhile to leave no stone unturned before trying again. Starting in the late 1990s, doctors testing fertilized eggs classified them as normal or abnormal, then added the classification "mosaic" in 2015. I know it only takes one good embryo to be successful and I understand the odds of having a good enough embryo to send for testing and having that testing turn out normal is very small. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. Inconclusive or No Result biopsies may require a second round of biopsy aka a rebiopsy. By 40 theres about a 1 in 4 chance of not getting a euploid and by 43 this doubles to half. Weve discussed euploid embryos, mosaic embryos, so what about aneuploid embryos? I feel like most times the protocol for autoimmune issues is the same. If you have not I would suggest an embryo scratch/biopsy before your next FET. Your clinic may have a better idea of how things work in their hands. Whitney et al. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. More info in my profile about my testing and treatment, and Im open to answering any questions. The thing we did differently for this one was adding an antihistamine protocol. Well start with euploids, then mosaics, and end with fully aneuploid embryos. For more up-to-date information on this topic check out my other posts that are tagged withEmbryo rebiopsy. Have you been tested for APS (antiphosolipid syndrome)? Best of luck to you. Im absolutely going to ask for biopsy and check for endometritis. A doctor can confirm it by testing blood for human chorionic gonadotropin (hCG . Some of the issues with the studies included in the meta-analysis were brought up: Future studies should focus on single embryo transfers, and in women >35, to see if PGT-A truly has a reduction in miscarriage rates for this age group. Please specify a reason for deleting this reply from the community. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. Im going to try and run it by her again to see what she thinks. also did you have to do another stim cycle? This is exactly what I had! We had two from #4 cycle- one normal boy embryo and another that they said they didn't have enough material to test. We have one day 7/Euploid Blast 5BB remaining on ice. It was a chemical pregnancy. Currently 8 weeks. Miscarriage of PGT tested embryo. I needed additional days of progesterone and that was corrected for my 2nd FET. - 2 Day 5's transferred ended in a chemical pregnancy; 1 perfect Day 6 blast ended up making me a mom. Sending you positive thoughts . So they were both frozen on Day 6? We PGS tested the whole batch of embryos at once at the end of all the retrievals. So what gives now?? Preliminary studies examine the rebiopsy and transfer of chaotic embryos by PGT-A. These studies were particularly small so drawing conclusions isnt really possible yet. My lining a week before transfer was 6.8, but trilaminar lining was present. These are said to help in cases with failed transfers or previous miscarriages because it calms down your system to accept the embryo, where without sometimes your immune response would attack it as something foreign. Of course the quality of the embryo is everything but there is significantly more uterine prep with a frozen transfer and I think it helped. Group Black's collective includes Essence, The Shade Room and Naturally Curly. My first FET failed and it was devastating. If you haven't had multiple losses/failed attempts feel free to comment but please be empathetic when doing so. In this post well learn more about IVF with PGS success rates for euploid embryos. We are absolutely crushed. Going into my second round of IVF I was doubting anything would work. , Ive done embryo glue every transfer but no luck unfortunately :(. Segmental mosaics or single chromosome mosaics tend to perform better than multiple chromosome abnormalities which can approach 50% miscarriage rates. You may want to ask/consider this before moving on for more data before trying with another precious embryo. It was an incredibly long and intense process but looking back I did not have time on my side for my eggs so it was the right decision for us.